Deregulated WNT signaling in childhood T-cell acute lymphoblastic leukemia

@inproceedings{Ng2014DeregulatedWS,
  title={Deregulated WNT signaling in childhood T-cell acute lymphoblastic leukemia},
  author={Ozden Hatirnaz Ng and Yucel Erbilgin and S Firtina and Tiraje T{\"u}lin Celkan and Zeynep Karakas and Gonul Aydogan and Emine Turkkan and Y Yildirmak and Cetin Timur and Emel Zengin and Jacques J. M. van Dongen and Frank J. T. Staal and Ugur Ozbek and Muge Sayitoglu},
  booktitle={Blood cancer journal},
  year={2014}
}
WNT signaling has been implicated in the regulation of hematopoietic stem cells and plays an important role during T-cell development in thymus. Here we investigated WNT pathway activation in childhood T-cell acute lymphoblastic leukemia (T-ALL) patients. To evaluate the potential role of WNT signaling in T-cell leukomogenesis, we performed expression analysis of key components of WNT pathway. More than 85% of the childhood T-ALL patients showed upregulated β-catenin expression at the protein… CONTINUE READING

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