Deregulated Myc requires MondoA/Mlx for metabolic reprogramming and tumorigenesis.

@article{Carroll2015DeregulatedMR,
  title={Deregulated Myc requires MondoA/Mlx for metabolic reprogramming and tumorigenesis.},
  author={Patrick Andrew Carroll and Daniel Diolaiti and Lisa G. McFerrin and Haiwei Gu and Danijel Djukovic and Jianhai Du and Pei Cheng and Sarah Anderson and Michelle Ulrich and James B Hurley and Daniel Raftery and Donald E. Ayer and Robert N. Eisenman},
  journal={Cancer cell},
  year={2015},
  volume={27 2},
  pages={271-85}
}
Deregulated Myc transcriptionally reprograms cell metabolism to promote neoplasia. Here we show that oncogenic Myc requires the Myc superfamily member MondoA, a nutrient-sensing transcription factor, for tumorigenesis. Knockdown of MondoA, or its dimerization partner Mlx, blocks Myc-induced reprogramming of multiple metabolic pathways, resulting in apoptosis. Identification and knockdown of genes coregulated by Myc and MondoA have allowed us to define metabolic functions required by deregulated… CONTINUE READING
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