Deregulated MHC class II transactivator expression leads to a strong Th2 bias in CD4+ T lymphocytes.

@article{Otten2003DeregulatedMC,
  title={Deregulated MHC class II transactivator expression leads to a strong Th2 bias in CD4+ T lymphocytes.},
  author={Luc A. Otten and Fabienne Tacchini-Cottier and Michael Lohoff and Francesco Annunziato and Lorenzo Cosmi and L{\'e}onardo Scarpellino and Jacques Louis and Viktor Steimle and Walter Reith and Hans Acha-Orbea},
  journal={Journal of immunology},
  year={2003},
  volume={170 3},
  pages={1150-7}
}
The MHC class II (MHC-II) transactivator (CIITA) is the master transcriptional regulator of genes involved in MHC-II-restricted Ag presentation. Fine tuning of CIITA gene expression determines the cell type-specific expression of MHC-II genes. This regulation is achieved by the selective usage of multiple CIITA promoters. It has recently been suggested that CIITA also contributes to Th cell differentiation by suppressing IL-4 expression in Th1 cells. In this study, we show that endogenous CIITA… CONTINUE READING

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