Derailed regulates development of the Drosophila neuromuscular junction.

  title={Derailed regulates development of the Drosophila neuromuscular junction.},
  author={Faith L. W. Liebl and Yuping Wu and David E Featherstone and Jasprina N. Noordermeer and Lee G Fradkin and Huey Hing},
  journal={Developmental neurobiology},
  volume={68 2},
Neural function is dependent upon the proper formation and development of synapses. We show here that Wnt5 regulates the growth of the Drosophila neuromuscular junction (NMJ) by signaling through the Derailed receptor. Mutations in both wnt5 and drl result in a significant reduction in the number of synaptic boutons. Cell-type specific rescue experiments show that wnt5 functions in the presynaptic motor neuron while drl likely functions in the postsynaptic muscle cell. Epistatic analyses… CONTINUE READING