Derailed estrogen signaling and breast cancer: an authentic couple.

@article{Manavathi2013DerailedES,
  title={Derailed estrogen signaling and breast cancer: an authentic couple.},
  author={Bramanandam Manavathi and Oindrilla Dey and Vijay Narsihma Reddy Gajulapalli and Raghavendra Singh Bhatia and Suresh Bugide and Rakesh Kumar},
  journal={Endocrine reviews},
  year={2013},
  volume={34 1},
  pages={
          1-32
        }
}
Estrogen or 17β-estradiol, a steroid hormone, plays a critical role in the development of mammary gland via acting through specific receptors. In particular, estrogen receptor-α (ERα) acts as a transcription factor and/or a signal transducer while participating in the development of mammary gland and breast cancer. Accumulating evidence suggests that the transcriptional activity of ERα is altered by the action of nuclear receptor coregulators and might be responsible, at least in part, for the… CONTINUE READING
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