• Corpus ID: 91136321

Der Einfluss der Chromatinfaltung auf die Remodeling-Aktivität der ATPase ISWI

@inproceedings{Hepp2017DerED,
  title={Der Einfluss der Chromatinfaltung auf die Remodeling-Aktivit{\"a}t der ATPase ISWI},
  author={Nicolas Hepp},
  year={2017}
}
............................................................................................................................................ 2 1 EINLEITUNG ................................................................................................................................... 3 1.1 AUFBAU UND STRUKTUR VON CHROMATIN ................................................................................... 3 1.1.1 Stufen der Chromatin-Kondensation… 

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TLDR
The aim of this book is to provide a Discussion of the Foundations of Sequence Variation in SATELLITE DNA, and Specific Variations in Tandem Repeats, and their Applications in Satellites.
Regulation of ISWI involves inhibitory modules antagonized by nucleosomal epitopes
TLDR
The ISWI ATPase catalytic core is an intrinsically active DNA translocase that conducts nucleosome sliding, onto which selective ‘inhibition-of-inhibition’ modules are placed, to help ensure that remodelling occurs only in the presence of proper nucleosomal epitopes.
Regulation of ISWI chromatin remodelling activity
TLDR
The different ways by which ISWI enzymatic activity can be modulated and regulated in the nucleus of eukaryotic cells are reviewed.
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TLDR
It is shown how a chromatin remodelling factor could set the spacing between two adjacent nucleosomes acting as a ‘protein ruler’, which would suggest that ISW1a uses a dinucleosome substrate for chromatic remodelling.
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TLDR
The approach is ideal for studying structures and conformations of proteins that are not amenable to conventional structural techniques, and shows the ATPase lobes strongly rotated against each other, a movement postulated earlier to be necessary to achieve a catalytically competent state.
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TLDR
It is proposed that the C-terminal domains of Isw2 are involved in anchoring the complex to nucleosomes through their interactions with linker DNA and that they facilitate the movement of DNA along the surface of nucleosome.
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TLDR
It is concluded that the H4 tail is critically required for nucleosome remodeling and spacing at a step subsequent to interaction with the substrate.
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TLDR
It is shown by quantitative biochemical means that all fundamental aspects of nucleosome remodeling are contained within the compact ATPase module of Drosophila ISWI.
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TLDR
This study finds that chromatin remodeling by SWI/SNF and ISW2 involves DNA translocation inside nucleosomes two helical turns from the dyad axis at superhelical location-2.
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