Depth-wise progression of osteoarthritis in human articular cartilage: investigation of composition, structure and biomechanics.

@article{Saarakkala2010DepthwisePO,
  title={Depth-wise progression of osteoarthritis in human articular cartilage: investigation of composition, structure and biomechanics.},
  author={Simo Saarakkala and Petro Julkunen and Panu Kiviranta and Jaana M{\"a}kitalo and Jukka S. Jurvelin and R K Korhonen},
  journal={Osteoarthritis and cartilage},
  year={2010},
  volume={18 1},
  pages={73-81}
}
OBJECTIVE Osteoarthritis (OA) is characterized by the changes in structure and composition of articular cartilage. However, it is not fully known, what is the depth-wise change in two major components of the cartilage solid matrix, i.e., collagen and proteoglycans (PGs), during OA progression. Further, it is unknown how the depth-wise changes affect local tissue strains during compression. Our aim was to address these issues. METHODS Data from the previous microscopic and biochemical… CONTINUE READING
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