Depsipeptide Companeramides from a Panamanian Marine Cyanobacterium Associated with the Coibamide Producer

@inproceedings{Vining2015DepsipeptideCF,
  title={Depsipeptide
Companeramides from a Panamanian Marine
Cyanobacterium Associated with the Coibamide Producer},
  author={Oliver B. Vining and Rebecca A. Medina and Edward A. Mitchell and Patrick Videau and Dong Li and Jeffrey D. Serrill and Jane Xu Kelly and William H Gerwick and Philip J Proteau and Jane E Ishmael and Kerry L McPhail},
  booktitle={Journal of natural products},
  year={2015}
}
Two new cyclic depsipeptides, companeramides A (1) and B (2), have been isolated from the phylogenetically characterized cyanobacterial collection that yielded the previously reported cancer cell toxin coibamide A (collected from Coiba Island, Panama). The planar structures of the companeramides, which contain 3-amino-2-methyl-7-octynoic acid (Amoya), hydroxy isovaleric acid (Hiva), and eight α-amino acid units, were established by NMR spectroscopy and mass spectrometry. The absolute… CONTINUE READING

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