Deprotection of Nin-formyl tryptophan using 1,2-ethanedithiol in liquid hydrogen fluoride. Deformylation upon HF treatment of Merrifield peptidyl-resins.

  • Gary Matsueda
  • Published 1982 in
    International journal of peptide and protein…

Abstract

Deprotection of Nin-formyl tryptophan (Trp) occurs during liquid hydrogen fluoride treatment at 0 degrees when 1,2-ethanedithiol (EDT), or 1,4-butanedithiol, is present. Deformylation, as evidenced by amino acid analysis and ultraviolet spectral analysis, is complete after 10 min at 0 degrees when Trp(CHO) is treated with HF:anisole:EDT(85:10:5) or HF:EDT… (More)

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@article{Matsueda1982DeprotectionON, title={Deprotection of Nin-formyl tryptophan using 1,2-ethanedithiol in liquid hydrogen fluoride. Deformylation upon HF treatment of Merrifield peptidyl-resins.}, author={Gary Matsueda}, journal={International journal of peptide and protein research}, year={1982}, volume={20 1}, pages={26-34} }