Depressor and regionally-selective vasodilator effects of human and rat urotensin II in conscious rats.

@article{Gardiner2001DepressorAR,
  title={Depressor and regionally-selective vasodilator effects of human and rat urotensin II in conscious rats.},
  author={Sheila M. Gardiner and Julie E. March and Philip A. Kemp and Anthony P. Davenport and Terence Bennett},
  journal={British journal of pharmacology},
  year={2001},
  volume={132 8},
  pages={
          1625-9
        }
}
The regional haemodynamic effects of rat or human urotensin II (U-II) 3, 30, 300 and 3000 pmol kg(-1), i.v.) were assessed in separate groups of conscious, unrestrained, male, Sprague-Dawley rats (n=8 in each). Rat and human U-II had similar effects. At a dose of 3 pmol kg(-1), neither peptide had any significant action, while at a dose of 30 pmol kg(-1), there was a transient mesenteric vasodilatation (significant only for rat U-II). At doses of 300 and 3000 pmol kg(-1), there were dose… CONTINUE READING

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