Depressive mood modulates the anterior lateral CA1 and DG/CA3 during a pattern separation task in cognitively intact individuals: a functional MRI study.

@article{Fujii2014DepressiveMM,
  title={Depressive mood modulates the anterior lateral CA1 and DG/CA3 during a pattern separation task in cognitively intact individuals: a functional MRI study.},
  author={Takeshi Fujii and Daisuke N. Saito and Hisakazu T. Yanaka and Hirotaka Kosaka and Hidehiko Okazawa},
  journal={Hippocampus},
  year={2014},
  volume={24 2},
  pages={214-24}
}
Although patients with major depressive disorder typically have a reduced hippocampal volume, particularly in the cornu ammonis 1 (CA1), animal studies suggest that depressive mood is related to the dentate gyrus (DG). In this study, our objective was to clarify which hippocampal subregions are functionally associated with depressive mood in humans. We conducted a functional MRI (fMRI) study on 27 cognitively intact volunteers. Subjects performed a modified version of a delayed matching-to… CONTINUE READING

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