Depressive-like profile induced by MCH microinjections into the dorsal raphe nucleus evaluated in the forced swim test.

@article{Lagos2011DepressivelikePI,
  title={Depressive-like profile induced by MCH microinjections into the dorsal raphe nucleus evaluated in the forced swim test.},
  author={Patr{\'i}cia E. D. Lagos and Jessika Urbanavicius and Mar{\'i}a Cecilia Scorza and Rodrigo Miraballes and Pablo Torterolo},
  journal={Behavioural brain research},
  year={2011},
  volume={218 2},
  pages={259-66}
}
Antagonism of the melanin-concentrating hormone (MCH) receptor 1 (MCH-R1) has been recently shown to have antidepressant-like profile in rats. However, the mechanisms by which the MCHergic system participates in the modulation of emotional states are still to be determined. In the present study we confirmed the presence of MCHergic fibers within the dorsal raphe nucleus (DRN), a serotonergic nucleus involved in the physiopathology of major depression. We also assessed the effects of the… CONTINUE READING

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In the present study we confirmed the presence of MCHergic fibers within the dorsal raphe nucleus ( DRN ) , a serotonergic nucleus involved in the physiopathology of major depression . We also assessed the effects of the administration of MCH and anti - MCH antibody ( immunoneutralization ) into the DRN using the forced swim test in rats , an animal model to screen antidepressant drugs .
In the present study we confirmed the presence of MCHergic fibers within the dorsal raphe nucleus ( DRN ) , a serotonergic nucleus involved in the physiopathology of major depression . We also assessed the effects of the administration of MCH and anti - MCH antibody ( immunoneutralization ) into the DRN using the forced swim test in rats , an animal model to screen antidepressant drugs .
In the present study we confirmed the presence of MCHergic fibers within the dorsal raphe nucleus ( DRN ) , a serotonergic nucleus involved in the physiopathology of major depression . We also assessed the effects of the administration of MCH and anti - MCH antibody ( immunoneutralization ) into the DRN using the forced swim test in rats , an animal model to screen antidepressant drugs .
In the present study we confirmed the presence of MCHergic fibers within the dorsal raphe nucleus ( DRN ) , a serotonergic nucleus involved in the physiopathology of major depression . We also assessed the effects of the administration of MCH and anti - MCH antibody ( immunoneutralization ) into the DRN using the forced swim test in rats , an animal model to screen antidepressant drugs .
In the present study we confirmed the presence of MCHergic fibers within the dorsal raphe nucleus ( DRN ) , a serotonergic nucleus involved in the physiopathology of major depression . We also assessed the effects of the administration of MCH and anti - MCH antibody ( immunoneutralization ) into the DRN using the forced swim test in rats , an animal model to screen antidepressant drugs .
In the present study we confirmed the presence of MCHergic fibers within the dorsal raphe nucleus ( DRN ) , a serotonergic nucleus involved in the physiopathology of major depression . We also assessed the effects of the administration of MCH and anti - MCH antibody ( immunoneutralization ) into the DRN using the forced swim test in rats , an animal model to screen antidepressant drugs .
In the present study we confirmed the presence of MCHergic fibers within the dorsal raphe nucleus ( DRN ) , a serotonergic nucleus involved in the physiopathology of major depression . We also assessed the effects of the administration of MCH and anti - MCH antibody ( immunoneutralization ) into the DRN using the forced swim test in rats , an animal model to screen antidepressant drugs .
In the present study we confirmed the presence of MCHergic fibers within the dorsal raphe nucleus ( DRN ) , a serotonergic nucleus involved in the physiopathology of major depression . We also assessed the effects of the administration of MCH and anti - MCH antibody ( immunoneutralization ) into the DRN using the forced swim test in rats , an animal model to screen antidepressant drugs .
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