Depressive-like effects of the kappa opioid receptor agonist salvinorin A are associated with decreased phasic dopamine release in the nucleus accumbens

@article{Ebner2010DepressivelikeEO,
  title={Depressive-like effects of the kappa opioid receptor agonist salvinorin A are associated with decreased phasic dopamine release in the nucleus accumbens},
  author={Stephanie R. Ebner and Mitchell F. Roitman and David N. Potter and Anna B. Rachlin and Elena H. Chartoff},
  journal={Psychopharmacology},
  year={2010},
  volume={210},
  pages={241-252}
}
Kappa opioid receptors (KORs) have been implicated in depressive-like states associated with chronic administration of drugs of abuse and stress. Although KOR agonists decrease dopamine in the nucleus accumbens (NAc), KOR modulation of phasic dopamine release in the core and shell subregions of the NAc—which have distinct roles in reward processing—remains poorly understood. Studies were designed to examine whether the time course of effects of KOR activation on phasic dopamine release in the… CONTINUE READING
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