Depressive-like behavior induced by tumor necrosis factor-α in mice

@article{Kaster2012DepressivelikeBI,
  title={Depressive-like behavior induced by tumor necrosis factor-α in mice},
  author={Manuella Pinto Kaster and Vin{\'i}cius de Maria Gadotti and Jo{\~a}o Batista Calixto and Adair Roberto Soares dos Santos and Ana L{\'u}cia S Rodrigues},
  journal={Neuropharmacology},
  year={2012},
  volume={62},
  pages={419-426}
}
Pro-inflammatory cytokines are implicated in the pathogenesis of depression. However, few animal models of cytokine-induced depression well characterized regarding its response to antidepressants are available. Hence, the aim of this study was to propose a model of depressive-like behavior induced by the administration of tumor necrosis factor-α (TNF-α) responsive to antidepressant treatments. TNF-α administered by i.c.v. route produced a depressive-like behavior in the forced swimming test… CONTINUE READING
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