Depressive-Like Effects of the κ-Opioid Receptor Agonist Salvinorin A on Behavior and Neurochemistry in Rats

  title={Depressive-Like Effects of the $\kappa$-Opioid Receptor Agonist Salvinorin A on Behavior and Neurochemistry in Rats},
  author={William A. Carlezon and Cécile Béguin and Jennifer A Dinieri and Michael H Baumann and Michele R Richards and Mark S. Todtenkopf and Richard B. Rothman and Zhong-ze Ma and David Y.W. Lee and Bruce M Cohen},
  journal={Journal of Pharmacology and Experimental Therapeutics},
  pages={440 - 447}
Endogenous opioids seem to play a critical role in the regulation of mood states. For example, there is accumulating evidence that stimulation of κ-opioid receptors, upon which the endogenous opioid dynorphin acts, can produce depressive-like behaviors in laboratory animals. Here we examined whether systemic administration of salvinorin A (SalvA), a potent and highly selective κ-opioid agonist, would produce depressive-like effects in the forced swim test (FST) and intracranial self-stimulation… 

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