Depressive-Like Effects of the κ-Opioid Receptor Agonist Salvinorin A on Behavior and Neurochemistry in Rats
@article{Carlezon2006DepressiveLikeEO, title={Depressive-Like Effects of the $\kappa$-Opioid Receptor Agonist Salvinorin A on Behavior and Neurochemistry in Rats}, author={William A. Carlezon and C{\'e}cile B{\'e}guin and Jennifer A Dinieri and Michael H Baumann and Michele R Richards and Mark S. Todtenkopf and Richard B. Rothman and Zhong-ze Ma and David Y.W. Lee and Bruce M Cohen}, journal={Journal of Pharmacology and Experimental Therapeutics}, year={2006}, volume={316}, pages={440 - 447} }
Endogenous opioids seem to play a critical role in the regulation of mood states. For example, there is accumulating evidence that stimulation of κ-opioid receptors, upon which the endogenous opioid dynorphin acts, can produce depressive-like behaviors in laboratory animals. Here we examined whether systemic administration of salvinorin A (SalvA), a potent and highly selective κ-opioid agonist, would produce depressive-like effects in the forced swim test (FST) and intracranial self-stimulation…
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ATPM-ET, at doses from 0.5 to 2 mg/kg, produced anxiolytic- and antidepressant-like effects without inducing aversive emotion, and were more closely mediated by activation of κ receptor than μ receptor.
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Repeated Exposure to the κ-Opioid Receptor Agonist Salvinorin A Modulates Extracellular Signal-Regulated Kinase and Reward Sensitivity
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A single injection of a novel kappa opioid receptor agonist salvinorin A attenuates the expression of cocaine-induced behavioral sensitization in rats
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SalvA and ketamine have previously under-appreciated similarities in their behavioral effects and pharmacological profiles, and KORs might be involved in some of the cognitive abnormalities observed in psychiatric disorders such as schizophrenia.
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