Depression subtyping based on evolutionary psychiatry: Proximate mechanisms and ultimate functions

  title={Depression subtyping based on evolutionary psychiatry: Proximate mechanisms and ultimate functions},
  author={Markus J. Rantala and Severi Luoto and Indrikis A. Krams and Hasse Karlsson},
  journal={Brain, Behavior, and Immunity},

Introducing a depression-like syndrome for translational neuropsychiatry: a plea for taxonomical validity and improved comparability between humans and mice.

The DLS approach uses a combined heuristic method based on clinical depression criteria and the Research Domain Criteria to provide a biobehavioural reference syndrome for preclinical rodent models of depression to gradually develop into an inter-model validation standard and microframework to improve phenotyping methodology in translational research.

Identifying the Subtypes of Major Depressive Disorder Based on Somatic Symptoms: A Longitudinal Study Using Latent Profile Analysis

The results indicate that somatic symptoms should be emphasized in patients with MDD, and more attention is needed for those with moderate somatic Symptoms, which may be relevant to a worse prognosis.

Neurodevelopmental theory of depression

Risk Factors for Adult Depression: Adverse Childhood Experiences and Personality Functioning

Patients presenting adverse childhood experiences are more likely to develop deficiencies in personality functioning, which in turn increases their likelihood of developing depressive symptomatology, reaffirm the importance of incorporating risk and vulnerability factors such as personality functioning in understanding depression.

Eating Disorders: An Evolutionary Psychoneuroimmunological Approach

The mismatch hypothesis is presented as a necessary extension to the current theoretical framework of eating disorders, and it is indicated that between-individual and within-individual variation in eating disorders partially arises from (co)variation in gut microbiota and stress responsivity, which influence neuroinflammation and the serotonergic system.

DSM-5 Criteria and Depression Severity: Implications for Clinical Practice

Depressed Mood was the most reliable symptom to discriminate ND from MD and Anhedonia discriminated SD from MD, and depression severity may be inferred based on the DSM-5 criteria.

Major Depressive Disorder in Older Patients as an Inflammatory Disorder: Implications for the Pharmacological Management of Geriatric Depression

Despite the evidence for the role of inflammation in depression, there is insufficient evidence to recommend use of any putative anti-inflammatory agent in the treatment of depression in older adults at this stage.



Subtyping Major Depressive Disorder

The DSM broad diagnosis of MDD does not encourage a search for subtypes of depression that may require specific treatment, and the current diagnostic system may be partly responsible for the rising placebo response rates and increasing numbers of subjects required to demonstrate efficacy in ever larger clinical trials.

Meta-review of depressive subtyping models.

Data-driven subtypes of major depressive disorder: a systematic review

The studies performed to date do not provide conclusive evidence for the existence of depressive symptom dimensions or symptomatic subtypes of depression, and the wide diversity of identified factors and classes might result from the absence of patterns to be found.

Understanding the somatic consequences of depression: biological mechanisms and the role of depression symptom profile

The heterogeneity of the depression concept seems to play a differentiating role: metabolic syndrome and inflammation up-regulations appear more specific to the atypical depression subtype, whereas hypercortisolemia appears more specific for melancholic depression.

The varied clinical presentations of major depressive disorder.

  • A. Rush
  • Psychology, Medicine
    The Journal of clinical psychiatry
  • 2007
A brief review of the status of several of the most common subtypes of DMS-IV major depressive disorder in terms of their clinical features, biological correlates, course of illness, and treatment implications is provided.

Evolutionary origins of depression: a review and reformulation.

  • D. Nettle
  • Psychology
    Journal of affective disorders
  • 2004

Organization of the stress system and its dysregulation in melancholic and atypical depression: high vs low CRH/NE states

The mediators and circuitries of the stress system are reviewed to lay the groundwork for placing in context physiologic and structural alterations in depression that may occur as part of stress system dysfunction.