Depression-related variation in brain morphology over 3 years: effects of stress?

  title={Depression-related variation in brain morphology over 3 years: effects of stress?},
  author={Thomas Frodl and Nikolaos Koutsouleris and Ronald Bottlender and Christine Born and Markus J{\"a}ger and Isabel Scupin and Maximilian Reiser and Hans-J{\"u}rgen M{\"o}ller and Eva M. Meisenzahl},
  journal={Archives of general psychiatry},
  volume={65 10},
CONTEXT Results of experimental studies suggest that neuroplastic changes may occur during depressive episodes. These effects have not been confirmed in patients with depression, to our knowledge. OBJECTIVE To examine changes in the brains of patients with major depression vs those of healthy control subjects. DESIGN Prospective longitudinal 3-year study. SETTING Inpatients with major depression were recruited from the Department of Psychiatry and Psychotherapy, Ludwig Maximilians… CONTINUE READING