Depression of stimulated arachidonate metabolism and superoxide production in rat alveolar macrophages following in vivo exposure to 0.5 ppm NO2.

@article{Robison1993DepressionOS,
  title={Depression of stimulated arachidonate metabolism and superoxide production in rat alveolar macrophages following in vivo exposure to 0.5 ppm NO2.},
  author={Timothy W. Robison and J K Murphy and Lisa Beyer and Arnis Richters and Henry Jay Forman},
  journal={Journal of toxicology and environmental health},
  year={1993},
  volume={38 3},
  pages={273-92}
}
Alveolar macrophages (AM) have been found to suffer significant functional deficits in response to nitrogen dioxide (NO2) exposure. The present investigation examined changes in the activation of AM arachidonate metabolism and superoxide production in response to an environmentally relevant level of NO2. Rats were exposed to 0.5 ppm NO2 for periods of 0.5-10 d and AM were obtained by bronchoalveolar lavage (BAL). NO2 exposure produced complex effects upon both unstimulated and stimulated AM… CONTINUE READING