Depression of peak force without altering calcium sensitivity by the superoxide anion in chemically skinned cardiac muscle of rat.

@article{MacFarlane1992DepressionOP,
  title={Depression of peak force without altering calcium sensitivity by the superoxide anion in chemically skinned cardiac muscle of rat.},
  author={Niall G. MacFarlane and D J Miller},
  journal={Circulation research},
  year={1992},
  volume={70 6},
  pages={1217-24}
}
Among the mechanisms postulated to contribute to myocardial "stunning" is a depression of contractility by oxygen-derived free radicals. It has been suggested that these radicals might depress the calcium sensitivity of the contractile proteins. We have exposed the myofilaments (in chemically "skinned" rat cardiac muscle) to the superoxide anion and measured isometric force at controlled degrees of activation. Superoxide was generated by the xanthine/xanthine oxidase system: the effects to be… CONTINUE READING

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Molecular and cellular mechanisms of myocardial stunning.

Physiological reviews • 1999
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References

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Low pH inhibits the development of a rigor contracture in isolated chemically skinned cardiac trabeculae of the rat

GL Smith, DS Steele
J Physiol ( Lond ) • 1989

Urate production by human heart.

Journal of molecular and cellular cardiology • 1989

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