Depression of membrane-bound hydrolases by cimetidine in mouse renal basolateral and brush border.

@article{Gill1991DepressionOM,
  title={Depression of membrane-bound hydrolases by cimetidine in mouse renal basolateral and brush border.},
  author={Markus Gill and Sankar Nath Sanyal and M L Sareen},
  journal={Research in experimental medicine. Zeitschrift fur die gesamte experimentelle Medizin einschliesslich experimenteller Chirurgie},
  year={1991},
  volume={191 6},
  pages={437-48}
}
Oral administration of the antiulcerogenic drug, cimetidine, was studied on kidney-bound hydrolytic enzymes at three different dose levels (30 mg, 100 mg, and 2000 mg/kg body weight) and for single administration for 2 and 24 h, and daily administration for 15 days in mice. It significantly inhibited Na+, K(+)-ATPase, Mg(2+)-ATPase, and Ca2+, Mg(2+)-ATPase in the isolated basolateral membrane (BLM). Brush-border-membrane-(BBM)-associated enzymes, sucrase, lactase, maltase, leucine… CONTINUE READING