Depression of immune competence by phenytoin and carbamazepine. Studies in vivo and in vitro.

@article{Sorrell1975DepressionOI,
  title={Depression of immune competence by phenytoin and carbamazepine. Studies in vivo and in vitro.},
  author={Tania Christine Sorrell and I. J. Forbes},
  journal={Clinical and experimental immunology},
  year={1975},
  volume={20 2},
  pages={273-85}
}
Depression of one or more parameters of cellular and/or humoral immune responses was found in 60% of general hospital patients treated with phenytoin and 47% of patients treated with carbamazepine. Phenytoin-treated patients failed to manifest delayed hypersensitivity (DHS) reactions to common antigens, and to make antibody to Salmonella typhi and tetanus toxoid. Serum levels of IgA and IgM, DNA synthesis in circulating leucocytes, and phytohaemagglutinin (PHA) induced deoxyribonucleic acid… CONTINUE READING