Depression of glutathione content, elevation of CYP2E1-dependent activation, and the principal determinant of the fasting-mediated enhancement of 1,3-dichloro-2-propanol hepatotoxicity in the rat.

@article{Fry1999DepressionOG,
  title={Depression of glutathione content, elevation of CYP2E1-dependent activation, and the principal determinant of the fasting-mediated enhancement of 1,3-dichloro-2-propanol hepatotoxicity in the rat.},
  author={Jeffrey R. Fry and David Sinclair and Carla Hagen Piper and Scott Townsend and Norman W. Thomas},
  journal={Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association},
  year={1999},
  volume={37 4},
  pages={351-5}
}
The influence of fasting (18 hours) on the hepatotoxicity of 1,3-dichloro-2-propanol (1,3-DCP) and on various hepatic parameters has been assessed in the rat. Fasting produced an enhancement of the hepatotoxicity which was associated with alterations in a variety of hepatic parameters when measured relative to protein content, most notably glutathione (GSH… CONTINUE READING