Depression of LTP in rat dentate gyrus by naloxone is reversed by GABAA blockade.

@article{Xie1995DepressionOL,
  title={Depression of LTP in rat dentate gyrus by naloxone is reversed by GABAA blockade.},
  author={C W Xie and Darrell V. Lewis},
  journal={Brain research},
  year={1995},
  volume={688 1-2},
  pages={56-60}
}
Long-term potentiation (LTP) of the lateral perforant path (LPP) to dentate granule cell (DGC) synapse is suppressed by the opioid antagonist, naloxone, and thus appears to be dependent upon the release of endogenous opioids from the LPP. It has been suggested that endogenous opioids enhance LTP by depressing GABAA inhibition. As one test of this hypothesis, we determined whether blockade of GABAA inhibition would alleviate the naloxone block of LTP in the LPP. Consistent with the hypothesis… CONTINUE READING

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