Depression-like behavior in the forced swimming test in PACAP-deficient mice: amelioration by the atypical antipsychotic risperidone.

@article{Hashimoto2009DepressionlikeBI,
  title={Depression-like behavior in the forced swimming test in PACAP-deficient mice: amelioration by the atypical antipsychotic risperidone.},
  author={Hitoshi Hashimoto and Ryota Hashimoto and Norihito Shintani and Kazuhiro Tanaka and Akiko Yamamoto and Michiyoshi Hatanaka and Xiaohong Guo and Yoshiko Morita and Mamoru Tanida and Katsuya Nagai and Masatoshi Takeda and A. Ramesha Baba},
  journal={Journal of neurochemistry},
  year={2009},
  volume={110 2},
  pages={595-602}
}
Pituitary adenylate cyclase-activating polypeptide (PACAP) is a neuropeptide with pleiotropic functions. We report here that PACAP-deficient (PACAP-/-) mice showed increased immobility in a forced swimming test, which was reduced by the antidepressant desipramine, to a similar extent as in wild-type mice. The atypical antipsychotic risperidone and the selective serotonin (5-HT)(2) antagonist ritanserin normalized the depression-like behavior in PACAP-/- mice. The 5-HT(2) agonist (+/-)-2,5… CONTINUE READING

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