Depression is associated with low plasma Abeta42 independently of cardiovascular disease in the homebound elderly.

@article{Qiu2007DepressionIA,
  title={Depression is associated with low plasma Abeta42 independently of cardiovascular disease in the homebound elderly.},
  author={Wei Qiao Qiu and Xiaoyan Sun and Dennis J Selkoe and David Mkaya Mwamburi and Tina Huang and Refeeque Bhadela and Peter R Bergethon and Tammy M Scott and Paul Summergrad and Lixia Wang and Irwin H Rosenberg and Marshal F. Folstein},
  journal={International journal of geriatric psychiatry},
  year={2007},
  volume={22 6},
  pages={536-42}
}
BACKGROUND Depression often precedes the onset of Alzheimer's disease (AD) before the appearance of cognitive symptoms. Plasma Amyloid-beta peptide 42 (Abeta42) declines before and soon after the onset of AD, yet the relationship between plasma Abeta42 and depression is unclear. METHODS We used 515 homebound elders aged 60 and older in a population-based, cross-sectional study to investigate associations between plasma Abeta levels and depression with and without cardiovascular co-morbidities… CONTINUE READING

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