Depression in the elderly

  title={Depression in the elderly},
  author={George S. Alexopoulos},
  journal={The Lancet},

Assessment scales for geriatric patients

Vulnerability to late-life depression is principally caused by aging-related and disease-related processes, including arteriosclerosis, inflammatory, endocrine, and immune changes that compromise the integrity of frontolimbic pathways.

Treatment of Depression in the Elderly: A Systematic Review

The selective serotonin reuptake inhibitors have replaced tricyclic antidepressants as first-line therapy when antidepressants are indicated, and electroconvulsive therapy offers a safe and effective alternative for patients refractory to or unable to tolerate antidepressant medication.

Mechanisms and treatment of late-life depression

Computerized cognitive remediation targeting functions of the cognitive control network may improve both executive functions and depressive symptoms of late-life major depression andStreamlined, stepped psychotherapies targeting behaviors assumed to result from dysfunction of brain networks implicated in late- life depression can be easy to learn and have potential for dissemination.

Depression, disability and somatic diseases among elderly.

Cerebrovascular Diseases: Post-stroke Depression and Anhedonia

Since stroke survivors frequently suffer from depression, research has focused on the incidence, phenomenology, course and risk factors of post-stroke depression, paying special attention to the biological explanatory models, such as the lesion location and vascular depression hypotheses.

Depression and cancer: an unexplored and unresolved emergent issue in elderly patients.

Neurobiology and Risk Factors of Late-Life Depression

This chapter seeks to review the research performed in this field over the last several decades, describing disturbances in fronto-subcortical function, genetic polymorphisms, chronic stress and inflammation, as well as vascular pathology.

Depression and Neurovascular Disease

Evidence from clinical, neuropsychological, neuroimaging, and post-mortem studies supports vascular depression as a distinct clinical entity and phenotype of late-life depression.



Depressed mood and the incidence of Alzheimer's disease in the elderly living in the community.

Depressed mood moderately increased the risk of developing dementia, primarily Alzheimer's disease.

Diagnosis and treatment of depression in late life.

Since depression in late life tends to be at least as chronic and/or recurrent as depression earlier in life, treatment for acute depressive episodes should last at least 6-8 months, and long-term maintenance treatment should be considered in selected individuals.

Executive Dysfunction, Heart Disease Burden, and Remission of Geriatric Depression

The findings of this study provide the rationale for investigation of the role of specific frontostriatal-limbic pathways in predisposing to geriatric depression or worsening its course.

Clinical presentation of the "depression-executive dysfunction syndrome" of late life.

Depressive symptomatology, and especially psychomotor retardation and loss of interest in activities, contributed to disability in DED patients, whereas paranoia was associated with disability independently of executive dysfunction.

The expert consensus guideline series. Pharmacotherapy of depressive disorders in older patients.

A consensus survey of expert opinion on the pharmacotherapy of depressive disorders in older patients to address clinical questions not definitively answered in the research literature reached a high level of consensus on the appropriateness of including both antidepressant medication, specifically SSRIs, and nonpharmacological modalities in treatment plans for severe depression.

Predicting caregiver burden and depression in Alzheimer's disease.

Alternative models of caregiver burden were tested using an unusually large sample size of participants and after overcoming methodological limitations of past research, highlighting the importance of the effective management of disturbing behaviors, the provision of formal services for caregivers with highly impaired patients and no informal support, and the improvement of coping skills in burdened caregivers.

Biological risk factors in late life depression

  • K. Krishnan
  • Medicine, Psychology
    Biological Psychiatry
  • 2002

Diagnosis and Treatment of Depression in Late Life: Results of the Nih Consensus Development Conference

A meta-analysis of treatment options in depressed elderly patients and diagnosis and treatment considerations in depression associated with late-life bereavement, as well as clinical and etiological heterogeneity of mood disorders in elderly patients, are reviewed.