Depression in an animal model: focus on the locus ceruleus.

  title={Depression in an animal model: focus on the locus ceruleus.},
  author={Jay Michael Weiss and P G Simson},
  journal={Ciba Foundation symposium},
When rats are exposed to highly stressful events over which they have no control, they subsequently show many of the symptoms seen in depression in humans. In the attempt to discover neurochemical factors underlying depression, the neurochemical basis of stress-induced behavioural depression in rats has been studied extensively. Initial research (1968-1976) indicated that behavioural depression in this model was produced by alteration of noradrenaline (NA) concentrations in the brain. More… CONTINUE READING

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