Depression in alpha-synucleinopathies: prevalence, pathophysiology and treatment.

  title={Depression in alpha-synucleinopathies: prevalence, pathophysiology and treatment.},
  author={Nadia Stefanova and Klaus Seppi and Christoph Scherfler and Zoe Puschban and Gregor Karl Wenning},
  journal={Journal of neural transmission. Supplementum},
Parkinson's disease (PD), dementia with Lewy bodies (DLB) and multiple system atrophy (MSA) are increasingly recognized as alpha-synucleinopathies, i.e. neurodegenerative disorders that share a common subcellular pathology characterized by alpha-synuclein abnormal aggregation. In the present review we focus on depression in alpha-synucleinopathies, discussing epidemiological, pathophysiological and treatment aspects of this frequently disabling clinical feature which may occur in PD, DLB and… CONTINUE READING