Depression impairs learning, whereas the selective serotonin reuptake inhibitor, paroxetine, impairs generalization in patients with major depressive disorder.

@article{Herzallah2013DepressionIL,
  title={Depression impairs learning, whereas the selective serotonin reuptake inhibitor, paroxetine, impairs generalization in patients with major depressive disorder.},
  author={Mohammad M. Herzallah and Ahmed A. Moustafa and Joman Y Natsheh and Omar A Danoun and Jessica R. Simon and Yasin Tayem and Mahmud A. Sehwail and Ivona Amleh and Issam Bannoura and Georgios Petrides and Catherine Myers and Mark A. Gluck},
  journal={Journal of affective disorders},
  year={2013},
  volume={151 2},
  pages={484-92}
}
To better understand how medication status and task demands affect cognition in major depressive disorder (MDD), we evaluated medication-naïve patients with MDD, medicated patients with MDD receiving the selective serotonin reuptake inhibitors (SSRI) paroxetine, and healthy controls. All three groups were administered a computer-based cognitive task with two phases, an initial phase in which a sequence is learned through reward-based feedback (which our prior studies suggest is striatal… CONTINUE READING
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