Depression but not seizure frequency predicts quality of life in treatment-resistant epilepsy

@article{Boylan2004DepressionBN,
  title={Depression but not seizure frequency predicts quality of life in treatment-resistant epilepsy},
  author={Laura S. Boylan and Lynn A. Flint and Daniel L. Labovitz and S C Jackson and Karen Starner and Orrin Devinsky},
  journal={Neurology},
  year={2004},
  volume={62},
  pages={258 - 261}
}
Background: The two-thirds of patients with epilepsy who become seizure-free have a quality of life (QOL) similar to the general population. The major treatment challenge is patients with refractory epilepsy. Whereas neurologists typically focus on seizure reduction in the treatment of these patients, results of studies relating seizure frequency to QOL are conflicting. As depression is associated with reduced QOL in epilepsy and antiepileptic medications (AEDs) can cause depression, it is… 

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