Depression associated with multiple sclerosis: an etiological conundrum.

  title={Depression associated with multiple sclerosis: an etiological conundrum.},
  author={A Feinstein},
  journal={Canadian journal of psychiatry. Revue canadienne de psychiatrie},
  volume={40 10},
  • A Feinstein
  • Published 1995 in
    Canadian journal of psychiatry. Revue canadienne…
OBJECTIVE Although depression frequently occurs in multiple sclerosis (MS), an association with cerebral pathology is unclear. This sets MS apart from other common neurological disorders. The reasons for this are explored. METHOD The literature on depression and magnetic resonance imaging (MRI) is reviewed and methodological issues are critically evaluated. RESULTS Failure to demonstrate cerebral correlates of depression is in part a function of poor study design. However, the diffuse… CONTINUE READING