Depression as a spreading neuronal adjustment disorder.

  title={Depression as a spreading neuronal adjustment disorder.},
  author={Jaanus Harro and Lars Oreland},
  journal={European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology},
  volume={6 3},
The outlines of a theory of the pathophysiology of depression are presented. The classic monoamine theory of depression as well as its more recent elaborations suggests that a deficit in monoamine neurotransmitters in the synaptic cleft is the primary cause of depression. We suggest that the primary defect emerges in the regulation of firing rates in brainstem monoaminergic neurons, which brings about a decrease in the tonic release of neurotransmitters in their projection areas, an increase in… CONTINUE READING