Depression and epilepsy: Epidemiologic and neurobiologic perspectives that may explain their high comorbid occurrence

  title={Depression and epilepsy: Epidemiologic and neurobiologic perspectives that may explain their high comorbid occurrence},
  author={Andres M. Kanner and Steven C. Schachter and John J. Barry and Dale C. Hersdorffer and Marco Mula and M. R. Trimble and Bruce Hermann and Alan E. Ettinger and David Dunn and Rochelle Caplan and Philippe Ryvlin and Frank G Gilliam},
  journal={Epilepsy \& Behavior},

Psychiatric and behavioral comorbidities in epilepsy: A critical reappraisal

D diagnostic errors between epilepsy and psychogenic nonepileptic seizures need careful consideration when evaluating studies demonstrating associations between psychiatric disorders and epilepsy or poorer seizure control in association with psychiatric disorders in people who have epilepsy.

Epilepsy coexisting with depression.

Neurocognitive and psychiatric markers of network disease in epilepsy

It is revealed that chronic seizures beginning in childhood dysregulate cognition-related networks important for autobiographic recall, while autobiographic memory impairments in patients with a more recent disease onset are largely linked to depressive symptoms, perhaps reflecting maladaptive psychological adjustment to the onset of epilepsy as an adult.

Epilepsy Associated Depression: An Update on Current Scenario, Suggested Mechanisms, and Opportunities.

Common pathological mechanisms such as neuroinflammation, dysregulated hypothalamus pituitary adrenal axis, altered neurogenesis, and altered tryptophan metabolism responsible for coexistent relationship of epilepsy and depression are reviewed and novel targets and therapeutic approaches for safe management of comorbid depression in epilepsy are suggested.

Neurobehavioral comorbidities of epilepsy: Role of inflammation

It appears likely that priming of the brain due to early inflammation could provide a means by which subsequent inflammatory processes associated with epilepsy, ASD, and depression may lead to comorbidity.


This article aims to produce a comprehensive review of the epidemiological considerations, clinical findings and management strategies for depression associated with epilepsy.



Depression and Epilepsy: A New Perspective on Two Closely Related Disorders

  • A. Kanner
  • Psychology, Medicine
    Epilepsy currents
  • 2006
Patients with suicidal ideation, psychotic symptoms, or bipolar disorders should be referred immediately to the care of a psychiatrist, and Neurologists should be well trained to provide psychopharmacologic treatment for major depressive episodes, dysthymic disorders, and minor depression.

Acute unstable depressive syndrome (AUDS) is associated more frequently with epilepsy than major depression

AUDS patients present with rapidly fluctuating mood symptoms, motor agitation and relative lack of insight and concern and it is suggested that the study of AUDS patients may offer a new approach to better understanding epilepsy and its association with depressive disorders.

Consensus statement: The evaluation and treatment of people with epilepsy and affective disorders

Phenomenology of Depression in Epilepsy

The depression in patients with epilepsy represents the outcome of multiple factors in genetically predisposed individuals, and patients receiving phenobarbital or carbamazepine were both less depressed and less anxious.

5-HT1A Receptor Binding in Temporal Lobe Epilepsy Patients With and Without Major Depression

The psychoses of epilepsy

The author describes the various manifestations of psychosis in epileptic patients, reviews the mechanisms for development of psychosis and offers practical advice on treatment, and analyzes the associations between seizures, temporal lobe abnormalities, and psychoses, especially in epilepsyptic patients presenting with symptoms of schizophrenia.

Suicide and epilepsy

It is important to take an holistic approach when evaluating and monitoring people with epilepsy and choose the right antiepileptic drug to use based on the presence of depression or suicidal ideation.