Depression and antisocial personality disorder: two contrasting disorders of 5HT function.

@article{Deakin2003DepressionAA,
  title={Depression and antisocial personality disorder: two contrasting disorders of 5HT function.},
  author={J F William Deakin},
  journal={Journal of neural transmission. Supplementum},
  year={2003},
  volume={64},
  pages={79-93}
}
Impaired 5HT functioning has been implicated in two very different psychiatric syndromes: antisocial personality disorder and depression. In both, reduced csf concentration of 5HIAA and blunted circulating hormone responses to 5HT drug challenge have been described. The paradox can be resolved by the theory that the two main ascending 5HT pathways mediate adaptive responses to future and current adversity. Projections of the anterior group of raphe 5HT cells (dorsal raphe nucleus) oppose the… CONTINUE READING