Depression and Cardiac Disease: Epidemiology, Mechanisms, and Diagnosis

  title={Depression and Cardiac Disease: Epidemiology, Mechanisms, and Diagnosis},
  author={Jeff C. Huffman and Christopher M. Celano and Scott Richard Beach and Shweta R. Motiwala and James Louis Januzzi},
  booktitle={Cardiovascular psychiatry and neurology},
In patients with cardiovascular disease (CVD), depression is common, persistent, and associated with worse health-related quality of life, recurrent cardiac events, and mortality. Both physiological and behavioral factors-including endothelial dysfunction, platelet abnormalities, inflammation, autonomic nervous system dysfunction, and reduced engagement in health-promoting activities-may link depression with adverse cardiac outcomes. Because of the potential impact of depression on quality of… CONTINUE READING