Depression‐like behavior in the forced swimming test in PACAP‐deficient mice: amelioration by the atypical antipsychotic risperidone

@article{Hashimoto2009DepressionlikeBI,
  title={Depression‐like behavior in the forced swimming test in PACAP‐deficient mice: amelioration by the atypical antipsychotic risperidone},
  author={H. Hashimoto and R. Hashimoto and N. Shintani and K. Tanaka and A. Yamamoto and Michiyoshi Hatanaka and X. Guo and Yoshiko Morita and M. Tanida and K. Nagai and M. Takeda and A. Baba},
  journal={Journal of Neurochemistry},
  year={2009},
  volume={110}
}
  • H. Hashimoto, R. Hashimoto, +9 authors A. Baba
  • Published 2009
  • Medicine, Biology
  • Journal of Neurochemistry
  • Pituitary adenylate cyclase‐activating polypeptide (PACAP) is a neuropeptide with pleiotropic functions. We report here that PACAP‐deficient (PACAP−/−) mice showed increased immobility in a forced swimming test, which was reduced by the antidepressant desipramine, to a similar extent as in wild‐type mice. The atypical antipsychotic risperidone and the selective serotonin (5‐HT)2 antagonist ritanserin normalized the depression‐like behavior in PACAP−/− mice. The 5‐HT2 agonist (±)‐2,5‐dimethoxy‐4… CONTINUE READING
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