Depression: the case for a monoamine deficiency.

  • Pilar Delgado
  • Published 2000 in The Journal of clinical psychiatry

Abstract

The monoamine hypothesis of depression predicts that the underlying pathophysiologic basis of depression is a depletion in the levels of serotonin, norepinephrine, and/or dopamine in the central nervous system. This hypothesized pathophysiology appears to be supported by the mechanism of action of antidepressants: agents that elevate the levels of these… (More)

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