Depression: chronophysiology and chronotherapy

  title={Depression: chronophysiology and chronotherapy},
  author={Dorr{\`a} Dridi and Amina Zouiten and Hedi ben Mansour},
  journal={Biological Rhythm Research},
  pages={77 - 91}
Depressed patients often show altered circadian rhythms, sleep disturbances, and diurnal mood variation. Decreased latency of rapid eye movement (REM) sleep, reduction in slow wave sleep, and abnormalities in the timing of REM/nonREM sleep cycles have all been reported in patients with major depressive disorder (MDD). It is thus evident that an understanding of the basic mechanisms of sleep regulation is essential, for a better analysis of the pathophysiology of depressive disorders. The aim of… Expand
9 Citations
Circadian rhythm and sleep alterations in older people with lifetime depression: a case-control study
Circadian advancement and alterations to the timing of sleep and REM onset are evident in older people with lifetime major depression, despite having only mild residual symptoms. Expand
Depressive disorders: Processes leading to neurogeneration and potential novel treatments
Novel treatments targeting immune dysfunction, oxidative stress and circadian rhythm misalignment (rather than primarily the monoaminergic system) may hold promise for truly disease modifying treatments that may prevent neurodegeneration rather than simply alleviating symptoms with no curative intent. Expand
Circadian preference and its relationship with possible sleep and awake bruxism in adults assisted by the public health system.
Compared with the evening circadian preference, the morning circadian preference was associated with greater protection against possible SB in an adult population assisted by the FHS. Expand
Distribution of Active and Resting Periods in the Motor Activity of Patients with Depression and Schizophrenia
There are important differences in control systems regulating motor behavior in these two major groups of psychiatric disorders, Patients with schizophrenia and depression have distinctly different profiles with regard to the characterization and distribution of active and inactive periods. Expand
A study of the mechanism of small-molecule soybean-protein-derived peptide supplement to promote sleep in a mouse model
Here, the effects of dietary supplementation with small-molecule soybean-protein-derived peptide (SBP) on sleep duration in mice are described. The amounts of the neurotransmitters tryptophan (Trp,Expand
Agomelatine is relatively a new anti-depressant in comparison to other selective serotonin reuptake inhibitors used in medicine. A stability-indicating high performance liquid chromatographicExpand
A New Validated Stability Indicating Liquid Chromatographic Method for the Determination of Agomelatine
Agomelatine is a melatonergic anti-depressant. A stability-indicating high performance liquid chromatographic technique was developed for the determination of Agomelatine in pharmaceuticalExpand
Novel stability indicating RP-HPLC method for the determination of Agomelatine-A novel antidepressant
A novel and simple reverse phase liquid chromatographic method was established for the determination of Agomelatine in presence of degradants. Agomelatine is used for the treatment of prostateExpand
Agomelatine and Depressions
  • G. Laux
  • NeuroPsychopharmacotherapy
  • 2021


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  • Psychology, Medicine
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The results have implications for analyzing diurnal variation of mood in unipolar and bipolar affective disorders and sleep disturbances in other major psychiatric conditions such as chronic schizophrenia. Expand
[Sleep disturbances--cause or result of depression].
It is worthy to look closer into its regulatory effect on the disordered circadian rhythm, which is not only to give an antidepressive effect, but in a visible improvement of sleep architecture and functioning during the day. Expand
Circadian rhythm mechanisms in affective illness and in antidepressant drug action.
Experiments indicate that abnormally advanced rhythms are not merely an epiphenomenon but play an important role in the pathogenesis of depression, leading to the hypothesis that depression occurs in susceptible individuals when a sleep-sensitive phase of the circadian system becomes advanced from the first hours of waking into the last hours of sleep and interacts with sleep to cause depression. Expand
Sleep deprivation in depression: what do we know, where do we go?
The therapeutic effect of SD is postulated to be linked to changes in disturbed circadian- and sleep-wake-dependent phase relationships and concomitant increase of slow-wave-sleep pressure; additionally, SD-induced sleepiness may counteract the hyperarousal state in depression. Expand
Agomelatine, melatonin and depressive disorder
It is suggested that strategies designed to bring about resynchronisation of circadian rhythms should be therapeutically effective in depression, and that the circadian alteration may be necessary but is not sufficient for an antidepressant effect. Expand
Biological rhythm disturbances in mood disorders
  • A. Wirz-Justice
  • Psychology, Medicine
  • International clinical psychopharmacology
  • 2006
Chronobiology has provided efficacious non-pharmaceutical treatments for mood disorders (such as sleep deprivation or light therapy) as well as novel approaches to new drugs (e.g. agomelatine). Expand
Major depressive disorder, sleep EEG and agomelatine: an open-label study.
In conclusion agomelatine improved sleep continuity and quality and normalized the distribution of SWS sleep and delta power throughout the night. Expand
The Use of Chronobiotics in the Resynchronization of the Sleep–wake Cycle
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Circadian rhythms in depression and recovery: Evidence for blunted amplitude as the main chronobiological abnormality
The findings suggest that depression may be related both to a weakening of the coupling processes between internal pacemakers and to an abnormal sensitivity to environmental information. Expand
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Insomnia is a cardinal symptom of depression, side by side with alterations of mood and slowing down of psychomotor activities, and total deprivation of sleep for one night may damp down the depressive disorders, and so does partial sleep deprivation in the second part of the night during several days. Expand