Depression: an inflammatory illness?

@article{Krishnadas2012DepressionAI,
  title={Depression: an inflammatory illness?},
  author={Rajeev Krishnadas and Jonathan Cavanagh},
  journal={Journal of Neurology, Neurosurgery \& Psychiatry},
  year={2012},
  volume={83},
  pages={495 - 502}
}
  • R. KrishnadasJ. Cavanagh
  • Published 15 March 2012
  • Biology, Psychology, Medicine
  • Journal of Neurology, Neurosurgery & Psychiatry
Major depressive disorder (MDD) is associated with significant morbidity and mortality. Findings from preclinical and clinical studies suggest that psychiatric illnesses, particularly MDD, are associated with inflammatory processes. While it is unlikely that MDD is a primary ‘inflammatory’ disorder, there is now evidence to suggest that inflammation may play a subtle role in the pathophysiology of MDD. Most of the evidence that links inflammation to MDD comes from three observations: (a) one… 

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References

SHOWING 1-10 OF 88 REFERENCES

Is Depression an Inflammatory Disorder?

Evidence is examined in support of the idea that inflammation only contributes to depression in a subset of patients versus the possibility that the depressogenic effect of inflammatory activation is more widespread and varies depending on the degree of vulnerability any given individual evinces in interconnected physiologic systems known to be implicated in the etiology of MDD.

Depression and anxiety in inflammatory bowel disease: A review of comorbidity and management

Evidence‐based pharmacological and psychological treatments for anxiety and depression are reviewed and practical considerations in treating these conditions in the context of IBD to facilitate overall management of the IBD patient are discussed.

The Effect of Antidepressant Medication Treatment on Serum Levels of Inflammatory Cytokines: A Meta-Analysis

Overall, while pharmacological antidepressant treatment reduced depressive symptoms, it did not reduce serum levels of TNFα, but antidepressant treatment did reduce levels of IL-1β and possibly those ofIL-6, which are consistent with the possibility that inflammatory cytokines contribute to depressive symptoms and that antidepressants block the effects ofinflammatory cytokines on the brain.

Tumour necrosis factor blockade mediates altered serotonin transporter availability in rheumatoid arthritis: a clinical, proof-of-concept study

Major depressive disorder is an independent risk factor for both work disability and mortality in patients with RA and appears to be of pivotal importance in pathogenesis, based on evidence of Cytokine dysregulation and TNF.

Depression and Cardiac Disease: A Review

The routine screening of cardiac patients for depression is recommended when there are adequate mechanisms for management and referral, such as available consulting psychiatrists or care management programs that facilitate the delivery of pharmacologic and psychotherapeutic treatments in this vulnerable population.

Acute inflammation and negative mood: Mediation by cytokine activation

Cytokines sing the blues: inflammation and the pathogenesis of depression.

Pro-inflammatory biomakers in depression: Treatment with venlafaxine

  • J. PiletzA. Halaris C. DeVane
  • Biology, Medicine
    The world journal of biological psychiatry : the official journal of the World Federation of Societies of Biological Psychiatry
  • 2009
A concave quadratic equation described the associations between plasma venlafaxine concentrations and IL1β, T NFα, TNFα, and MCP-1, suggesting that these biomarkers may have become selectively lowered in the serotonergic dose range of venl Lafaxine.
...