Depression: an inflammatory illness?

  title={Depression: an inflammatory illness?},
  author={Rajeev Krishnadas and Jonathan Cavanagh},
  journal={Journal of Neurology, Neurosurgery \& Psychiatry},
  pages={495 - 502}
  • R. KrishnadasJ. Cavanagh
  • Published 15 March 2012
  • Biology, Psychology, Medicine
  • Journal of Neurology, Neurosurgery & Psychiatry
Major depressive disorder (MDD) is associated with significant morbidity and mortality. Findings from preclinical and clinical studies suggest that psychiatric illnesses, particularly MDD, are associated with inflammatory processes. While it is unlikely that MDD is a primary ‘inflammatory’ disorder, there is now evidence to suggest that inflammation may play a subtle role in the pathophysiology of MDD. Most of the evidence that links inflammation to MDD comes from three observations: (a) one… 

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Pro-inflammatory biomakers in depression: Treatment with venlafaxine

  • J. PiletzA. Halaris C. DeVane
  • Biology, Medicine
    The world journal of biological psychiatry : the official journal of the World Federation of Societies of Biological Psychiatry
  • 2009
A concave quadratic equation described the associations between plasma venlafaxine concentrations and IL1β, T NFα, TNFα, and MCP-1, suggesting that these biomarkers may have become selectively lowered in the serotonergic dose range of venl Lafaxine.