Depression, social support, and beta-adrenergic transcription control in human ovarian cancer

@article{Lutgendorf2009DepressionSS,
  title={Depression, social support, and beta-adrenergic transcription control in human ovarian cancer},
  author={Susan K Lutgendorf and Koen Degeest and Caroline Y. Sung and J. Mart{\'i}n Ar{\'e}valo and Steve W. Cole},
  journal={Brain, Behavior, and Immunity},
  year={2009},
  volume={23},
  pages={176-183}
}
Motivated by previous indications that beta-adrenergic signaling can regulate tumor cell gene expression in model systems, we sought to determine whether similar dynamics occur in primary human ovarian cancer. DNA microarray analyses of 10 ovarian carcinomas identified 266 human transcripts that were differentially expressed in tumors from patients with elevated biobehavioral risk factors (high depressive symptoms and low social support) relative to grade- and stage-matched tumors from low-risk… CONTINUE READING
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