Depression, Circadian Rhythms and Trimipramine

  title={Depression, Circadian Rhythms and Trimipramine},
  author={Eckart Rüther},
SummaryDuring depression, chronobiological disorders occur, such as disturbances in body temperature and early urinary excretion of a noradrenaline metabolite. Sleep patterns are disturbed in 90% of depressed patients; early REM sleep and shortened slow-wave sleep (stages 3 and 4), resulting in an increase in REM sleep, have been observed. Thus, an increase in REM sleep may be an indication of depression. Chronic insomnia is characterised by irregular sleep behaviour, an anxious attitude to… 
1 Citations
Chronic psychosocial stress alters NPY system: Different effects in rat and tree shrew
Although evident species differences were found in response to chronic psychosocial stress, the present study suggests a role for NPY receptors in the stress response and in the action of antidepressant drugs, providing further support for an involvement of this neuropeptidergic system in the pathophysiology of depression and anxiety.


Electroencephalographic sleep profiles in recurrent depression. A longitudinal investigation.
The electroencephalographic sleep profile of a group of recurrent depressives who had been depressed for less than four weeks was compared with their sleep profile in a prior episode of depression, indicating that early in the episode, rapid eye movement (REM) sleep findings are more abnormal.
Circadian rhythm disorders in manic-depressives.
A circadian etiology is consistent with the genetics and age distribution of manic-depressive illness and affective disturbances could be evolutionary remnants of the photo-periodic seasonal responses in animals.
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Although the presence of circadian rhythms complicates the task of designing clinical research procedures, their early timing in manic-depressives suggests that disturbances in central biological clocks may be an integral part of the pathophysiology of affective illness and may be related to disturbances of sleep and neuroendocrine function associated with depression.
Polysomnographic findings in recently drug-free and clinically remitted depressed patients.
Whether PSG abnormalities identify clinically remitted patients who are prone to develop another depressive episode requires longitudinal follow-up studies.
Depression and daily temperature
Changes were found in the daily temperature rhythm which resulted in a temperature maximum earlier in the day during the depression, which can be explained as indicating a desynchronization phenomenon of the circadian rhythms.
Sleep Mechanisms and Pathophysiology: Some Clinical Implications of the Reciprocal Interaction Hypothesis of Sleep Cycle Control
The implications of the model for other processes of interest to psychosomatic medicine are explored, including hallucinoid psychosis; periodic mood disorders; sleep disorders, especially apnea; and epilepsy.
Angst, Depression und Schlafstörungen
Bekannt ist, das Schlafstorungen eng mit Angst und Depression gekoppelt sind. — In diesem Beitrag soll der Frage nachgegangen werden, ob es moglich ist, anhand von subjektiven und objektiven
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Die Frage nach der Differenzierung von Angst und Depression stellt sich im psychiatrischen Alltag recht haufig, weil fur beide Storungsbilder unterschiedliche Behandlungen als indiziert angesehen
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