Depression, Circadian Rhythms and Trimipramine

@article{Ruther2012DepressionCR,
  title={Depression, Circadian Rhythms and Trimipramine},
  author={Eckart Rüther},
  journal={Drugs},
  year={2012},
  volume={38},
  pages={1-3}
}
SummaryDuring depression, chronobiological disorders occur, such as disturbances in body temperature and early urinary excretion of a noradrenaline metabolite. Sleep patterns are disturbed in 90% of depressed patients; early REM sleep and shortened slow-wave sleep (stages 3 and 4), resulting in an increase in REM sleep, have been observed. Thus, an increase in REM sleep may be an indication of depression. Chronic insomnia is characterised by irregular sleep behaviour, an anxious attitude to… 
1 Citations
Chronic psychosocial stress alters NPY system: Different effects in rat and tree shrew
TLDR
Although evident species differences were found in response to chronic psychosocial stress, the present study suggests a role for NPY receptors in the stress response and in the action of antidepressant drugs, providing further support for an involvement of this neuropeptidergic system in the pathophysiology of depression and anxiety.

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