Depressing mitochondria-reticulum interactions protects cardiomyocytes from lethal hypoxia-reoxygenation injury.

@article{Paillard2013DepressingMI,
  title={Depressing mitochondria-reticulum interactions protects cardiomyocytes from lethal hypoxia-reoxygenation injury.},
  author={M{\'e}lanie Paillard and Emily Tubbs and Pierre-Alain Thi{\'e}baut and L. Villalpando G{\'o}mez and J{\'e}r{\'e}my Fauconnier and Claire Crola Da Silva and Geoffrey Teixeira and Nathan Mewton and Elise Belaidi and Annie Durand and Maryline Abrial and Alain Lacampagne and Jennifer Rieusset and Michel Ovize},
  journal={Circulation},
  year={2013},
  volume={128 14},
  pages={1555-65}
}
BACKGROUND Under physiological conditions, Ca(2+) transfer from the endoplasmic reticulum (ER) to mitochondria might occur at least in part at contact points between the 2 organelles and involves the VDAC1/Grp75/IP3R1 complex. Accumulation of Ca(2+) into the mitochondrial matrix may activate the mitochondrial chaperone cyclophilin D (CypD) and trigger permeability transition pore opening, whose role in ischemia/reperfusion injury is well recognized. We questioned here whether the transfer of Ca… CONTINUE READING

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