Depressed type 1 cytokine synthesis by superantigen-activated CD4+ T cells of women with human papillomavirus-related high-grade squamous intraepithelial lesions.

@article{Lee2004DepressedT1,
  title={Depressed type 1 cytokine synthesis by superantigen-activated CD4+ T cells of women with human papillomavirus-related high-grade squamous intraepithelial lesions.},
  author={B N Lee and Michele Follen and De-Yu Shen and Anais Malpica and Karen Adler-Storthz and William Thomas Shearer and James M. Reuben},
  journal={Clinical and diagnostic laboratory immunology},
  year={2004},
  volume={11 2},
  pages={239-44}
}
Carcinoma of the cervix is causally related to infection with the human papillomavirus (HPV), and T cells play a pivotal role in the immune response of the host to rid itself of HPV infection. Therefore, we assessed the T-cell function of women with HPV-related cervical neoplasia against a superantigen, Staphylococcus enterotoxin B (SEB). Each woman provided a cervical brush specimen for HPV DNA testing and Papanicolaou (Pap) smears for the staging of cervical lesions. They also provided a… CONTINUE READING