Depressed sensitivity of the hepatoportal NaCl receptors in rats with carbon tetrachloride-induced liver cirrhosis.

@article{Tanaka1995DepressedSO,
  title={Depressed sensitivity of the hepatoportal NaCl receptors in rats with carbon tetrachloride-induced liver cirrhosis.},
  author={Kumiko Tanaka and Tomoko Matsuda and Hironobu Morita and Hiroshi Hosomi},
  journal={The American journal of physiology},
  year={1995},
  volume={269 6 Pt 2},
  pages={R1390-5}
}
In normal rats, the activity of the hepatoportal NaCl-sensitive afferent nerves is increased by portal injection of hypertonic NaCl. In the present article, we have found this effect to be markedly reduced in rats with CCl4-induced liver cirrhosis (CT rats). Liver tissue norepinephrine content, a marker of tissue innervation, was also decreased in the treated rats. Over the 12 wk CCl4-treatment period, no significant difference in Na balance was found between control and CT rats when both… CONTINUE READING