Depressed mood and reality disturbance correlate with decreased nocturnal melatonin in depressed patients.

@article{Brown1987DepressedMA,
  title={Depressed mood and reality disturbance correlate with decreased nocturnal melatonin in depressed patients.},
  author={Richard P Brown and James Howard Kocsis and Stanley N Caroff and Jonathan Amsterdam and Andrew Winokur and Peter E. Stokes and Alan Frazer},
  journal={Acta psychiatrica Scandinavica},
  year={1987},
  volume={76 3},
  pages={272-5}
}
The authors measured serum samples of melatonin at 11:00 p.m. in 28 patients suffering from major depression. Melatonin secretion was inversely correlated with the depressed mood and reality disturbance factors of the Hamilton Depression Scale. These results are consistent with previous reports of low melatonin syndrome in a subgroup of depressed patients. 

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