Depressed hepatic glutathione and increased diene conjugates in alcoholic liver disease

  title={Depressed hepatic glutathione and increased diene conjugates in alcoholic liver disease},
  author={Dr. Spencer Shaw and Kenneth P. Rubin and Charles S. Lieber},
  journal={Digestive Diseases and Sciences},
The role of lipid peroxidation in the pathogenesis of alcoholic liver disease has been a subject of controversy. In order to study this question we measured hepatic glutathione and diene conjugates in liver biopsies from 16 alcoholics with different stages of liver injury and 8 nonalcoholics with liver disease. Patients with alcoholic liver disease were found to have decreased hepatic glutathione compared to patients with liver disease unrelated to alcohol (22.1±2.5 vs 33.5±4.6 nmol/mg protein… CONTINUE READING


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