Depressed glutathione synthesis precedes oxidative stress and atherogenesis in Apo-E(-/-) mice.

@article{Biswas2005DepressedGS,
  title={Depressed glutathione synthesis precedes oxidative stress and atherogenesis in Apo-E(-/-) mice.},
  author={Saibal K Biswas and David E. Newby and Irfan Rahman and Ian L Megson},
  journal={Biochemical and biophysical research communications},
  year={2005},
  volume={338 3},
  pages={1368-73}
}
Glutathione is a vital intracellular antioxidant. The enzymes involved in its synthesis and utilisation are tightly regulated, but the importance of glutathione regulation in atherogenesis is poorly understood. Here, we establish that glutathione is severely (approximately 80%) depleted very early (10 weeks) in the atheroma-prone aortic arch of male apoprotein E-deficient (Apo-E(-/-)) mice compared to age-matched wild-type controls. Importantly, this event pre-empts lipid peroxidation and… CONTINUE READING

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