Depressed fibrinolysis in patients with acute leukaemia.

  title={Depressed fibrinolysis in patients with acute leukaemia.},
  author={Anna Rita Guarini and Luciana Mussoni and Luigi Gugliotta and L Chetti and T. Niewiarowski and Lucia Catani and S Macchi and Maria Benedetta Donati and Sante Tura},
  journal={British journal of haematology},
  volume={66 3},
The fibrinolytic system was studied in 46 patients with acute leukaemia at diagnosis. Untreated patients (with the sole exception of the M3 subgroup) showed an inhibition of fibrinolytic activity, measured by the euglobulin lysis time and area. This inhibition was accompanied by reduced t-PA antigen and t-PA inhibitor activity. No correlation was found between the above-mentioned fibrinolytic parameters and the biochemical haematological values considered, nor with clinical and/or laboratory… CONTINUE READING