Depressed contractile responses to neurokinin A in idiopathic but not neurogenic overactive human detrusor muscle.


OBJECTIVE The role of tachykinins such as neurokinin A in regulating bladder function is unclear, but NK2 receptors seem to mediate contraction in the human bladder and it has been suggested that these peptides may have a role in the pathophysiology of bladder dysfunction. The present study investigates neurokinin receptor-mediated contractility of detrusor… (More)


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